The genomic architecture of host whole blood transcriptional response to malaria infection-GSE34404
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| Description | The genomic architecture of host whole blood transcriptional response to malaria infection |
| Purpose | Analysis of the effect of malaria infection on whole blood gene expression and uncovering regulatory effects using eQTL analysis. Testing for relashionships between genotype, expression and malaria phenotypes. |
| Experimental Design | We generated whole blood gene expression profiles and genotypes from 155 West-African children including 94 cases undergoing the symptomatic phase of blood-stage Plasmodium falciparum infection and 61 age-matched controls. PCA, analysis of covariance and eQTL analysis were performed on the data. |
| Methods | The data were normalised using quantile normalisation with JMP Genomics |
| Additional Information | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE34404 |
| Platform | Illumina HumanHT-12 v4 |
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