Sample Set Annotation Tool: Genome-wide profiling of whole blood from patients with defects in Toll-like receptors and IL-1Rs signaling-GSE25742

Study Design
Assay
Sample Info
Files
Info
Samples
Group Sets
Analysis

Purpose

The objective of this study is to: 1) Characterize the innate immune responsiveness of patients with inborn errors in Toll-IL1 receptor signaling pathway (IRAK4, MyD88 deficiencies) compared to healthy subjects, through the analysis of blood leukocytes' transcriptional profiles after stimulation with ligands for the whole set of Toll-like receptors and IL-1Rs plus whole bacteria. 2) Understand the redundancies in TLR pathway in humans. 3) Explore the use of blood profiling approaches to assess the immune status of an individual by using Primary Immune Deficiencies as a proof of principle.

Hypothesis

Experimental Design

A total of 22 blood samples were collected from three groups of subjects: 4 patients with complete MYD88 deficiency, 4 patients with complete IRAK4 deficiency, and 14 healthy donors. Mutations from IRAK4 and MYD88 patients are loss-of-function. The subjects were recruited in two different batches: first set includes 4 healthy controls, MYD88 P1 and P2, IRAK4 P1 and P2 patients. Second set includes 10 different healthy controls, MYD88 P3 and P4 and IRAK4 P3 and P4. Healthy individuals are considered so based on past medical history (no recurrent infections). They were also healthy at the time of sampling. From each subject, peripheral blood was drawn into sodium heparin vacuum tubes on clinic site (Necker Hospital, Paris). Right away, 500µl whole blood was diluted with the same amount of RPMI before adding different stimulus. Diluted whole blood was activated with a wide range of ligands (16 conditions total, see below) in a volume of 50 µl, for 2 hours along with 10µg/ml of polymyxin B to clear LPS contamination in reagents. Whole blood was lysated with Tempus solution (from Tempus tubes, Applied Biosystems) to stabilize the RNA at 1:3 ratio after restimulation. The lysates were kept at -80ºC temperature until mRNA extraction. A total of 365 samples were analyzed. Choice of agonists: PAM3 (TLR1/2) and PAM2 (TLR2/6), 100 ng/ml final concentration, Invivogen®; poly(I:C) 25 µg/ml final concentration, Invivogen® (TLR3); LPS 100 ng/ml final concentration, Sigma® (TLR4); Flagellin 100 ng/ml final concentration, Invivogen® (TLR5); 3M13 (TLR7) and 3M2 (TLR8), 3µg/ml final concentration, 3M pharmaceuticals®; R848 3µg/ml final concentration, Invivogen® (TLR7/8); CpG-D19 and CPG C (TLR9), 3µg/ml final concentration, from collaborator. Agonists for IL-1R: IL-1b 20ng/ml final concentration, IL18 and IL33 50ng/ml final concentration, from RaD systems®; agonist for TNFa receptor, TNFa, 20ng/ml final concentration, from RaD systems®; PMA 25 ng/ml + Ionomycin 1µg/ml final concentration, Sigma®; heat killed whole bacteria: 3 pneumococcal strains (R6, 5.106 partical/ml final concentration; R8450 108 partical/ml final concentration; R11470, 5.106 partical/ml final concentration, heat killed at 65°C for 15 min) from collaborator, and Staphylococcus aureus (SAC), 107 partical/ml final concentration, from Invivogen®. No stimulation serves as negative control and PMA/ionomycin stimulation as positive control.

Experimental Variables

Controls

Methods

Additional Information

Expected Samples:

225 Samples Loaded: 225

Species

Human (Homo sapiens)

Sample Source

Whole Blood

Disease

Primary Immunodeficiency

Treatment Protocol

Growth Protocol

Extraction Protocol

Storage Conditions

Sample Set Spreadsheet

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Samples Preview

Sample ID	Gender	Illness	!Sample_title	cell population	geographic
GSM632242	M	healthy control	control 6_polyIC	Whole blood	France
GSM632243	F	healthy control	control 3__3M2	Whole blood	France
GSM632245	M	healthy control	control 4__3M2	Whole blood	France
GSM632246	F	healthy control	control 3_IL-1b	Whole blood	France
GSM632247	M	healthy control	control 4_No stimulation	Whole blood	France

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Sample ID	Gender	Illness	!Sample Title	Cell population	Geographic	In vitro stimulation blood volume per condition	Age at enrollment	In vitro stimulation condition	Race	In vitro stimulation incubation time
GSM632242	M	healthy control	control 6_polyIC	Whole blood	France	1 ml	30	PolyIC	White	2h
GSM632243	F	healthy control	control 3__3M2	Whole blood	France	1 ml	42	3M2	White	2h
GSM632245	M	healthy control	control 4__3M2	Whole blood	France	1 ml	35	3M2	White	2h
GSM632246	F	healthy control	control 3_IL-1b	Whole blood	France	1 ml	42	IL1b	White	2h
GSM632247	M	healthy control	control 4_No stimulation	Whole blood	France	1 ml	35	No stimulation	White	2h
GSM632250	F	healthy control	control 5_PAM3	Whole blood	France	1 ml	45	PAM3	White	2h
GSM632251	F	healthy control	control 2_polyIC	Whole blood	France	1 ml	40	PolyIC	White	2h
GSM632255	M	healthy control	control 6_R8450	Whole blood	France	1 ml	30	R8450	White	2h
GSM632256	M	healthy control	control 6_Flagellin	Whole blood	France	1 ml	30	Flagellin	White	2h
GSM632257	M	healthy control	control 6_PMAIono	Whole blood	France	1 ml	30	PMAIono	White	2h
GSM632260	M	healthy control	control 4_R6	Whole blood	France	1 ml	35	R6	White	2h
GSM632261	M	healthy control	control 6_3M13	Whole blood	France	1 ml	30	3M13	White	2h
GSM632262	M	healthy control	control 4_R11470	Whole blood	France	1 ml	35	R11470	White	2h
GSM632269	M	healthy control	control 1_polyIC	Whole blood	Portugal	1 ml	38	PolyIC	White	2h
GSM632271	F	healthy control	control 2_CpG C	Whole blood	France	1 ml	40	CpG C	White	2h
GSM632273	F	healthy control	control 3_No stimulation	Whole blood	France	1 ml	42	No stimulation	White	2h
GSM632275	M	healthy control	control 6_CpG C	Whole blood	France	1 ml	30	CpG C	White	2h
GSM632276	F	healthy control	control 3_Flagellin	Whole blood	France	1 ml	42	Flagellin	White	2h
GSM632277	F	healthy control	control 3_IL33	Whole blood	France	1 ml	42	IL33	White	2h
GSM632280	M	healthy control	control 4_PMAIono	Whole blood	France	1 ml	35	PMAIono	White	2h
GSM632281	F	healthy control	control 2_CpG-D19	Whole blood	France	1 ml	40	CpGD19	White	2h
GSM632284	F	healthy control	control 3_polyIC	Whole blood	France	1 ml	42	PolyIC	White	2h
GSM632285	M	healthy control	control 1_CpG C	Whole blood	Portugal	1 ml	38	CpG C	White	2h
GSM632286	F	healthy control	control 2_3M13	Whole blood	France	1 ml	40	3M13	White	2h
GSM632287	M	healthy control	control 4_CpG-D19	Whole blood	France	1 ml	35	CpGD19	White	2h
GSM632289	F	healthy control	control 3_PAM3	Whole blood	France	1 ml	42	PAM3	White	2h
GSM632290	M	healthy control	control 4_IL-1b	Whole blood	France	1 ml	35	IL1b	White	2h
GSM632291	M	healthy control	control 6_TNFa	Whole blood	France	1 ml	30	TNFa	White	2h
GSM632293	M	healthy control	control 4_R8450	Whole blood	France	1 ml	35	R8450	White	2h
GSM632294	M	healthy control	control 6_LPS	Whole blood	France	1 ml	30	LPS	White	2h
GSM632296	F	healthy control	control 5_IL33	Whole blood	France	1 ml	45	IL33	White	2h
GSM632297	F	healthy control	control 2_No stimulation	Whole blood	France	1 ml	40	No stimulation	White	2h
GSM632299	M	healthy control	control 6__3M2	Whole blood	France	1 ml	30	3M2	White	2h
GSM632300	F	healthy control	control 5_No stimulation	Whole blood	France	1 ml	45	No stimulation	White	2h
GSM632301	M	healthy control	control 1_CpG-D19	Whole blood	Portugal	1 ml	38	CpGD19	White	2h
GSM632303	M	healthy control	control 1_No stimulation	Whole blood	Portugal	1 ml	38	No stimulation	White	2h
GSM632304	M	healthy control	control 6_No stimulation	Whole blood	France	1 ml	30	No stimulation	White	2h
GSM632305	F	healthy control	control 5_TNFa	Whole blood	France	1 ml	45	TNFa	White	2h
GSM632306	F	healthy control	control 3_PMAIono	Whole blood	France	1 ml	42	PMAIono	White	2h
GSM632307	F	healthy control	control 5_LPS	Whole blood	France	1 ml	45	LPS	White	2h
GSM632308	M	healthy control	control 4_Flagellin	Whole blood	France	1 ml	35	Flagellin	White	2h
GSM632309	F	healthy control	control 2_PMAIono	Whole blood	France	1 ml	40	PMAIono	White	2h
GSM632310	M	healthy control	control 6_R848	Whole blood	France	1 ml	30	R848	White	2h
GSM632311	F	healthy control	control 5_PMAIono	Whole blood	France	1 ml	45	PMAIono	White	2h
GSM632312	F	healthy control	control 2__3M2	Whole blood	France	1 ml	40	3M2	White	2h
GSM632313	F	healthy control	control 2_LPS	Whole blood	France	1 ml	40	LPS	White	2h
GSM632315	M	healthy control	control 6_IL-1b	Whole blood	France	1 ml	30	IL1b	White	2h
GSM632316	F	healthy control	control 2_Flagellin	Whole blood	France	1 ml	40	Flagellin	White	2h
GSM632317	F	healthy control	control 3_R848	Whole blood	France	1 ml	42	R848	White	2h
GSM632320	M	healthy control	control 7_CpG-D19	Whole blood	France	1 ml	40	CpGD19	White	2h
GSM632321	M	healthy control	control 9_R6	Whole blood	France	1 ml	31	R6	White	2h
GSM632323	M	healthy control	control 9_PAM3	Whole blood	France	1 ml	31	PAM3	White	2h
GSM632324	M	healthy control	control 7_Flagellin	Whole blood	France	1 ml	40	Flagellin	White	2h
GSM632325	M	healthy control	control 7_R11470	Whole blood	France	1 ml	40	R11470	White	2h
GSM632326	F	healthy control	control 8_R6	Whole blood	France	1 ml	42	R6	White	2h
GSM632327	M	healthy control	control 10_TNFa	Whole blood	Turkish	1 ml	33	TNFa	White	2h
GSM632329	F	healthy control	control 8_Flagellin	Whole blood	France	1 ml	42	Flagellin	White	2h
GSM632330	M	healthy control	control 10_PMAIono	Whole blood	Turkish	1 ml	31	PMAIono	White	2h
GSM632334	F	healthy control	control 8_polyIC	Whole blood	France	1 ml	42	PolyIC	White	2h
GSM632336	M	healthy control	control 7_R8450	Whole blood	France	1 ml	40	R8450	White	2h
GSM632337	M	healthy control	control 9_Flagellin	Whole blood	France	1 ml	31	Flagellin	White	2h
GSM632341	M	healthy control	control 7_No stimulation	Whole blood	France	1 ml	40	No stimulation	White	2h
GSM632342	F	healthy control	control 8_LPS	Whole blood	France	1 ml	42	LPS	White	2h
GSM632343	M	healthy control	control 7_PMAIono	Whole blood	France	1 ml	40	PMAIono	White	2h
GSM632345	F	healthy control	control 8__3M2	Whole blood	France	1 ml	42	3M2	White	2h
GSM632347	F	healthy control	control 8_CpG C	Whole blood	France	1 ml	42	CpG C	White	2h
GSM632349	M	healthy control	control 10_R848	Whole blood	Turkish	1 ml	33	R848	White	2h
GSM632350	M	healthy control	control 10_R6	Whole blood	Turkish	1 ml	33	R6	White	2h
GSM632355	F	healthy control	control 5_CpG-D19	Whole blood	France	1 ml	45	CpGD19	White	2h
GSM632356	M	healthy control	control 4_PAM2	Whole blood	France	1 ml	35	PAM2	White	2h
GSM632357	M	healthy control	control 6_SAC	Whole blood	France	1 ml	30	SAC	White	2h
GSM632358	M	healthy control	control 6_CpG-D19	Whole blood	France	1 ml	30	CpGD19	White	2h
GSM632359	F	healthy control	control 5_polyIC	Whole blood	France	1 ml	45	PolyIC	White	2h
GSM632360	M	healthy control	control 1_R848	Whole blood	Portugal	1 ml	38	R848	White	2h
GSM632361	F	healthy control	control 5__3M2	Whole blood	France	1 ml	45	3M2	White	2h
GSM632362	F	healthy control	control 5_Flagellin	Whole blood	France	1 ml	45	Flagellin	White	2h
GSM632363	M	healthy control	control 4_polyIC	Whole blood	France	1 ml	35	PolyIC	White	2h
GSM632364	F	healthy control	control 5_IL18	Whole blood	France	1 ml	45	IL18	White	2h
GSM632365	M	healthy control	control 1__3M2	Whole blood	Portugal	1 ml	38	3M2	White	2h
GSM632367	M	healthy control	control 4_CpG C	Whole blood	France	1 ml	35	CpG C	White	2h
GSM632369	M	healthy control	control 6_R6	Whole blood	France	1 ml	30	R6	White	2h
GSM632371	F	healthy control	control 5_CpG C	Whole blood	France	1 ml	45	CpG C	White	2h
GSM632373	M	healthy control	control 4_R848	Whole blood	France	1 ml	35	R848	White	2h
GSM632375	F	healthy control	control 5_3M13	Whole blood	France	1 ml	45	3M13	White	2h
GSM632376	M	healthy control	control 1_PAM3	Whole blood	Portugal	1 ml	38	PAM3	White	2h
GSM632377	M	healthy control	control 6_PAM3	Whole blood	France	1 ml	30	PAM3	White	2h
GSM632379	M	healthy control	control 4_SAC	Whole blood	France	1 ml	35	SAC	White	2h
GSM632380	M	healthy control	control 4_PAM3	Whole blood	France	1 ml	35	PAM3	White	2h
GSM632381	M	healthy control	control 4_TNFa	Whole blood	France	1 ml	35	TNFa	White	2h
GSM632382	F	healthy control	control 5_IL-1b	Whole blood	France	1 ml	45	IL1b	White	2h
GSM632383	M	healthy control	control 1_PAM2	Whole blood	Portugal	1 ml	38	PAM2	White	2h
GSM632384	M	healthy control	control 6_R11470	Whole blood	France	1 ml	30	R11470	White	2h
GSM632385	M	healthy control	control 6_IL18	Whole blood	France	1 ml	30	IL18	White	2h
GSM632386	F	healthy control	control 5_PAM2	Whole blood	France	1 ml	45	PAM2	White	2h
GSM632387	F	healthy control	control 3_TNFa	Whole blood	France	1 ml	42	TNFa	White	2h
GSM632388	F	healthy control	control 3_3M13	Whole blood	France	1 ml	42	3M13	White	2h
GSM632389	F	healthy control	control 2_R848	Whole blood	France	1 ml	40	R848	White	2h
GSM632390	M	healthy control	control 4_3M13	Whole blood	France	1 ml	35	3M13	White	2h
GSM632391	F	healthy control	control 5_R848	Whole blood	France	1 ml	45	R848	White	2h
GSM632392	F	healthy control	control 3_CpG-D19	Whole blood	France	1 ml	42	CpGD19	White	2h
GSM632394	M	healthy control	control 4_LPS	Whole blood	France	1 ml	35	LPS	White	2h
GSM632395	M	healthy control	control 4_IL18	Whole blood	France	1 ml	35	IL18	White	2h
GSM632397	M	healthy control	control 6_IL33	Whole blood	France	1 ml	30	IL33	White	2h
GSM632398	F	healthy control	control 3_CpG C	Whole blood	France	1 ml	42	CpG C	White	2h
GSM632399	M	healthy control	control 4_IL33	Whole blood	France	1 ml	35	IL33	White	2h
GSM632400	M	healthy control	control 9_PAM2	Whole blood	France	1 ml	31	PAM2	White	2h
GSM632401	M	healthy control	control 7_polyIC	Whole blood	France	1 ml	40	PolyIC	White	2h
GSM632402	M	healthy control	control 7_SAC	Whole blood	France	1 ml	40	SAC	White	2h
GSM632403	M	healthy control	control 9_IL18	Whole blood	France	1 ml	31	IL18	White	2h
GSM632404	M	healthy control	control 9_TNFa	Whole blood	France	1 ml	31	TNFa	White	2h
GSM632405	M	healthy control	control 9_R848	Whole blood	France	1 ml	31	R848	White	2h
GSM632407	F	healthy control	control 8_R848	Whole blood	France	1 ml	42	R848	White	2h
GSM632408	F	healthy control	control 8_PAM3	Whole blood	France	1 ml	42	PAM3	White	2h
GSM632409	M	healthy control	control 10_polyIC	Whole blood	Turkish	1 ml	33	PolyIC	White	2h
GSM632410	M	healthy control	control 7_R848	Whole blood	France	1 ml	40	R848	White	2h
GSM632412	M	healthy control	control 9_IL33	Whole blood	France	1 ml	31	IL33	White	2h
GSM632414	F	healthy control	control 8_IL-1b	Whole blood	France	1 ml	42	IL1b	White	2h
GSM632415	M	healthy control	control 10_PAM3	Whole blood	Turkish	1 ml	33	PAM3	White	2h
GSM632416	M	healthy control	control 10_3M13	Whole blood	Turkish	1 ml	33	3M13	White	2h
GSM632418	M	healthy control	control 7_CpG C	Whole blood	France	1 ml	40	CpG C	White	2h
GSM632419	F	healthy control	control 8_No stimulation	Whole blood	France	1 ml	42	No stimulation	White	2h
GSM632421	M	healthy control	control 10_CpG C	Whole blood	Turkish	1 ml	33	CpG C	White	2h
GSM632423	M	healthy control	control 10_CpG-D19	Whole blood	Turkish	1 ml	33	CpGD19	White	2h
GSM632424	M	healthy control	control 9_CpG C	Whole blood	France	1 ml	31	CpG C	White	2h
GSM632426	M	healthy control	control 7_IL33	Whole blood	France	1 ml	40	IL33	White	2h
GSM632428	M	healthy control	control 9_3M13	Whole blood	France	1 ml	31	3M13	White	2h
GSM632429	M	healthy control	control 10_SAC	Whole blood	France	1 ml	31	SAC	White	2h
GSM632430	M	healthy control	control 7_IL-1b	Whole blood	France	1 ml	40	IL1b	White	2h
GSM632431	M	healthy control	control 10_R11470	Whole blood	Turkish	1 ml	33	R11470	White	2h
GSM632432	M	healthy control	control 9_R8450	Whole blood	France	1 ml	31	R8450	White	2h
GSM632433	F	healthy control	control 8_CpG-D19	Whole blood	France	1 ml	42	CpGD19	White	2h
GSM632434	F	healthy control	control 8_SAC	Whole blood	France	1 ml	42	SAC	White	2h
GSM632435	M	healthy control	control 7_LPS	Whole blood	France	1 ml	40	LPS	White	2h
GSM632437	M	healthy control	control 9_IL-1b	Whole blood	France	1 ml	31	IL1b	White	2h
GSM632438	M	healthy control	control 9_polyIC	Whole blood	France	1 ml	31	PolyIC	White	2h
GSM632439	M	healthy control	control 9__3M2	Whole blood	France	1 ml	31	3M2	White	2h
GSM632440	F	healthy control	control 8_R8450	Whole blood	France	1 ml	42	R8450	White	2h
GSM632441	M	healthy control	control 10_LPS	Whole blood	Turkish	1 ml	33	LPS	White	2h
GSM632444	M	healthy control	control 10_IL33	Whole blood	Turkish	1 ml	33	IL33	White	2h
GSM632445	M	healthy control	control 9_LPS	Whole blood	France	1 ml	31	LPS	White	2h
GSM632446	F	healthy control	control 8_IL18	Whole blood	France	1 ml	42	IL18	White	2h
GSM632448	M	healthy control	control 9_No stimulation	Whole blood	France	1 ml	31	No stimulation	White	2h
GSM632449	M	healthy control	control 9_SAC	Whole blood	France	1 ml	33	SAC	White	2h
GSM632451	F	healthy control	control 8_PAM2	Whole blood	France	1 ml	42	PAM2	White	2h
GSM632453	F	healthy control	control 8_R11470	Whole blood	France	1 ml	42	R11470	White	2h
GSM632454	M	healthy control	control 10_Flagellin	Whole blood	Turkish	1 ml	33	Flagellin	White	2h
GSM632455	M	healthy control	control 10_No stimulation	Whole blood	Turkish	1 ml	33	No stimulation	White	2h
GSM632458	M	healthy control	control 7_IL18	Whole blood	France	1 ml	40	IL18	White	2h
GSM632459	M	healthy control	control 10_IL18	Whole blood	Turkish	1 ml	33	IL18	White	2h
GSM632461	M	healthy control	control 7_PAM3	Whole blood	France	1 ml	40	PAM3	White	2h
GSM632463	F	healthy control	control 8_TNFa	Whole blood	France	1 ml	42	TNFa	White	2h
GSM632464	M	healthy control	control 10_PAM2	Whole blood	Turkish	1 ml	33	PAM2	White	2h
GSM632465	M	healthy control	control 7_3M13	Whole blood	France	1 ml	40	3M13	White	2h
GSM632466	F	healthy control	control 8_3M13	Whole blood	France	1 ml	42	3M13	White	2h
GSM632468	F	healthy control	control 8_IL33	Whole blood	France	1 ml	42	IL33	White	2h
GSM632469	M	healthy control	control 10_IL-1b	Whole blood	Turkish	1 ml	33	IL1b	White	2h
GSM632470	M	healthy control	control 7_PAM2	Whole blood	France	1 ml	40	PAM2	White	2h
GSM632471	F	healthy control	control 8_PMAIono	Whole blood	France	1 ml	42	PMAIono	White	2h
GSM632472	M	healthy control	control 10_R8450	Whole blood	Turkish	1 ml	33	R8450	White	2h
GSM632473	M	healthy control	control 10__3M2	Whole blood	Turkish	1 ml	33	3M2	White	2h
GSM632475	M	healthy control	control 9_CpG-D19	Whole blood	France	1 ml	31	CpGD19	White	2h
GSM632477	M	healthy control	control 9_PMAIono	Whole blood	France	1 ml	31	PMAIono	White	2h
GSM632481	M	healthy control	control1_v1_PAM3	Whole blood	France	1 ml	28	PAM3	White	2h
GSM632482	M	healthy control	control1_v1_IL-1b	Whole blood	France	1 ml	28	IL1b	White	2h
GSM632483	M	healthy control	control4_v1_No stimulation	Whole blood	France	1 ml	35	No stimulation	White	2h
GSM632484	M	healthy control	control4_v1_3M13	Whole blood	France	1 ml	35	3M13	White	2h
GSM632485	M	healthy control	control4_v1_PMAIono	Whole blood	France	1 ml	35	PMAIono	White	2h
GSM632487	F	healthy control	control3_v1_R848	Whole blood	France	1 ml	34	R848	White	2h
GSM632488	M	healthy control	control1_v1_IL33	Whole blood	France	1 ml	28	IL33	White	2h
GSM632489	M	healthy control	control1_v1_IL18	Whole blood	France	1 ml	28	IL18	White	2h
GSM632496	M	healthy control	control4_v1__3M2	Whole blood	France	1 ml	35	3M2	White	2h
GSM632497	F	healthy control	control3_v1_TNFa	Whole blood	France	1 ml	34	TNFa	White	2h
GSM632498	M	healthy control	control1_v1_CpG C	Whole blood	France	1 ml	28	CpG C	White	2h
GSM632500	F	healthy control	control2_v1_Flagellin	Whole blood	France	1 ml	30	Flagellin	White	2h
GSM632507	F	healthy control	control3_v1_CpG-D19	Whole blood	France	1 ml	34	CpGD19	White	2h
GSM632508	M	healthy control	control1_v1_No stimulation	Whole blood	France	1 ml	28	No stimulation	White	2h
GSM632509	M	healthy control	control1_v1_PMAIono	Whole blood	France	1 ml	28	PMAIono	White	2h
GSM632511	F	healthy control	control3_v1__3M2	Whole blood	France	1 ml	34	3M2	White	2h
GSM632512	F	healthy control	control2_v1_LPS	Whole blood	France	1 ml	30	LPS	White	2h
GSM632516	M	healthy control	control1_v1_R848	Whole blood	France	1 ml	28	R848	White	2h
GSM632525	F	healthy control	control2_v1_IL33	Whole blood	France	1 ml	30	IL33	White	2h
GSM632526	M	healthy control	control4_v1_Flagellin	Whole blood	France	1 ml	35	Flagellin	White	2h
GSM632527	M	healthy control	control1_v1_CpG-D19	Whole blood	France	1 ml	28	CpGD19	White	2h
GSM632528	F	healthy control	control3_v1_IL18	Whole blood	France	1 ml	34	IL18	White	2h
GSM632531	F	healthy control	control2_v1_PMAIono	Whole blood	France	1 ml	30	PMAIono	White	2h
GSM632532	F	healthy control	control3_v1_CpG C	Whole blood	France	1 ml	34	CpG C	White	2h
GSM632533	F	healthy control	control2_v1_No stimulation	Whole blood	France	1 ml	30	No stimulation	White	2h
GSM632534	F	healthy control	control2_v1_TNFa	Whole blood	France	1 ml	30	TNFa	White	2h
GSM632535	M	healthy control	control1_v1_Flagellin	Whole blood	France	1 ml	28	Flagellin	White	2h
GSM632536	F	healthy control	control2_v1_CpG C	Whole blood	France	1 ml	30	CpG C	White	2h
GSM632538	F	healthy control	control2_v1_polyIC	Whole blood	France	1 ml	30	PolyIC	White	2h
GSM632539	M	healthy control	control1_v1_TNFa	Whole blood	France	1 ml	28	TNFa	White	2h
GSM632545	M	healthy control	control4_v1_IL33	Whole blood	France	1 ml	35	IL33	White	2h
GSM632549	M	healthy control	control4_v1_CpG-D19	Whole blood	France	1 ml	35	CpGD19	White	2h
GSM632552	F	healthy control	control1_v1_3M13	Whole blood	France	1 ml	28	3M13	White	2h
GSM632553	M	healthy control	control4_v1_TNFa	Whole blood	France	1 ml	35	TNFa	White	2h
GSM632555	M	healthy control	control4_v1_IL-1b	Whole blood	France	1 ml	35	IL1b	White	2h
GSM632556	F	healthy control	control2_v1_R848	Whole blood	France	1 ml	30	R848	White	2h
GSM632559	M	healthy control	control4_v1_IL18	Whole blood	France	1 ml	35	IL18	White	2h
GSM632560	M	healthy control	control4_v1_PAM3	Whole blood	France	1 ml	35	PAM3	White	2h
GSM632563	F	healthy control	control3_v1_IL-1b	Whole blood	France	1 ml	34	IL1b	White	2h
GSM632564	F	healthy control	control2_v1_IL18	Whole blood	France	1 ml	30	IL18	White	2h
GSM632569	F	healthy control	control3_v1_LPS	Whole blood	France	1 ml	34	LPS	White	2h
GSM632570	M	healthy control	control4_v1_R848	Whole blood	France	1 ml	35	R848	White	2h
GSM632574	F	healthy control	control2_v1_IL-1b	Whole blood	France	1 ml	30	IL1b	White	2h
GSM632576	F	healthy control	control2_v1__3M2	Whole blood	France	1 ml	30	3M2	White	2h
GSM632578	F	healthy control	control3_v1_polyIC	Whole blood	France	1 ml	34	PolyIC	White	2h
GSM632580	F	healthy control	control3_v1_PAM3	Whole blood	France	1 ml	34	PAM3	White	2h
GSM632582	M	healthy control	control1_v1_polyIC	Whole blood	France	1 ml	28	PolyIC	White	2h
GSM632583	F	healthy control	control3_v1_PAM2	Whole blood	France	1 ml	34	PAM2	White	2h
GSM632584	M	healthy control	control4_v1_PAM2	Whole blood	France	1 ml	35	PAM2	White	2h
GSM632585	F	healthy control	control3_v1_3M13	Whole blood	France	1 ml	34	3M13	White	2h
GSM632586	M	healthy control	control1_v1_LPS	Whole blood	France	1 ml	28	LPS	White	2h
GSM632587	F	healthy control	control3_v1_Flagellin	Whole blood	France	1 ml	34	Flagellin	White	2h
GSM632590	F	healthy control	control2_v1_CpG-D19	Whole blood	France	1 ml	30	CpGD19	White	2h
GSM632591	M	healthy control	control1_v1_PAM2	Whole blood	France	1 ml	28	PAM2	White	2h
GSM632594	M	healthy control	control1_v1__3M2	Whole blood	France	1 ml	28	3M2	White	2h
GSM632595	F	healthy control	control2_v1_PAM2	Whole blood	France	1 ml	30	PAM2	White	2h
GSM632596	M	healthy control	control4_v1_LPS	Whole blood	France	1 ml	35	LPS	White	2h
GSM632597	F	healthy control	control3_v1_PMAIono	Whole blood	France	1 ml	34	PMAIono	White	2h
GSM632599	F	healthy control	control2_v1_PAM3	Whole blood	France	1 ml	30	PAM3	White	2h
GSM632600	F	healthy control	control3_v1_IL33	Whole blood	France	1 ml	34	IL33	White	2h
GSM632602	M	healthy control	control4_v1_polyIC	Whole blood	France	1 ml	35	PolyIC	White	2h
GSM632603	M	healthy control	control4_v1_CpG C	Whole blood	France	1 ml	35	CpG C	White	2h
GSM632606	F	healthy control	control3_v1_No stimulation	Whole blood	France	1 ml	34	No stimulation	White	2h

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