| MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Affymetrix) |
| In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients providing a proof-of-principle that allograft tolerance is attainable in humans. The intra-graft molecular pathways associated with human allograft tolerance, however, have not been comprehensively studied before. In this study we analyzed sequential liver tissue samples collected from liver recipients enrolled in a prospective multicenter immunosuppressive withdrawal clinical trial. Tolerant and non-tolerant recipients differed in the intra-graft expression of genes involved in the regulation of iron homeostasis.These results point to a critical role of iron homeostasis in the regulation of intra-graft alloimmune responses in humans and provide a set of novel biomarkers to conduct drug-weaning trials in liver transplantation. |
--
The complete database comprised the expression measurements of 54,675 genes for liver inmunotolerance groups: 9 Tolerant (TOL) 10 Non Tolerant (Non TOL).A subset of 5 tolerant samples (TOL POST) were taken 1 year after inmunosuppresive therapy.
--
--
'gcrma' function of the Bioconductor package (v2.4) 'gcrma' in R.2.9.1
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi
| Sample ID | !Sample_title | immunotolerance group |
|---|---|---|
| GSM655318 | Liver biopsy before immunosuppressive therapy W111P | TOL |
| GSM655319 | Liver biopsy after immunosuppressive therapy W111PST | TOL POST |
| GSM655320 | Liver biopsy before immunosuppressive therapy W113P | TOL |
| GSM655321 | Liver biopsy after immunosuppressive therapy W113PST | TOL POST |
| GSM655322 | Liver biopsy before immunosuppressive therapy W120P | TOL |
| File |
|---|
All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.
| Sample ID | !Sample Title | Immunotolerance group |
|---|---|---|
| GSM655318 | Liver biopsy before immunosuppressive therapy W111P |
TOL |
| GSM655319 | Liver biopsy after immunosuppressive therapy W111PST |
TOL POST |
| GSM655320 | Liver biopsy before immunosuppressive therapy W113P |
TOL |
| GSM655321 | Liver biopsy after immunosuppressive therapy W113PST |
TOL POST |
| GSM655322 | Liver biopsy before immunosuppressive therapy W120P |
TOL |
| GSM655323 | Liver biopsy after immunosuppressive therapy W120PST |
TOL POST |
| GSM655324 | Liver biopsy before immunosuppressive therapy W129P |
TOL |
| GSM655325 | Liver biopsy after immunosuppressive therapy W129PST |
TOL POST |
| GSM655326 | Liver biopsy before immunosuppressive therapy W1P |
TOL |
| GSM655327 | Liver biopsy before immunosuppressive therapy W20P |
TOL |
| GSM655328 | Liver biopsy after immunosuppressive therapy W20PST |
TOL POST |
| GSM655329 | Liver biopsy before immunosuppressive therapy W3P |
TOL |
| GSM655330 | Liver biopsy before immunosuppressive therapy W11P |
Non TOL |
| GSM655331 | Liver biopsy before immunosuppressive therapy W12P |
Non TOL |
| GSM655332 | Liver biopsy before immunosuppressive therapy W15P |
Non TOL |
| GSM655333 | Liver biopsy before immunosuppressive therapy W21P |
Non TOL |
| GSM655334 | Liver biopsy before immunosuppressive therapy W2P |
Non TOL |
| GSM655335 | Liver biopsy before immunosuppressive therapy W37P |
TOL |
| GSM655336 | Liver biopsy before immunosuppressive therapy W40P |
Non TOL |
| GSM655337 | Liver biopsy before immunosuppressive therapy W65P |
Non TOL |
| GSM655338 | Liver biopsy before immunosuppressive therapy W81P |
Non TOL |
| GSM655339 | Liver biopsy before immunosuppressive therapy W83P |
Non TOL |
| GSM655340 | Liver biopsy before immunosuppressive therapy W89P |
Non TOL |
| GSM655341 | Liver biopsy before immunosuppressive therapy W8P |
TOL |
| Name | ||
|---|---|---|
| All Samples | View | |
| Group | Default | View |
| In order to make new Group Sets or change settings, please log in. | ||
| Group Set | |
|---|---|
| All Samples | |
| Group |