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MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Illumina) - GSE26625

In Progress
Clinical
MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Illumina)
Purpose

In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients providing a proof-of-principle that allograft tolerance is attainable in humans. The intra-graft molecular pathways associated with human allograft tolerance, however, have not been comprehensively studied before. In this study we analyzed sequential liver tissue samples collected from liver recipients enrolled in a prospective multicenter immunosuppressive withdrawal clinical trial. Tolerant and non-tolerant recipients differed in the intra-graft expression of genes involved in the regulation of iron homeostasis.These results point to a critical role of iron homeostasis in the regulation of intra-graft alloimmune responses in humans and provide a set of novel biomarkers to conduct drug-weaning trials in liver transplantation

Hypothesis

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Experimental Design

The complete database comprised the expression measurements of 48766 probes in liver biopsies. The liver biopsy specimens available for the study were obtained: a) before immunosuppressive drugs were discontinued from tolerant (TOL, n=24) and non-tolerant (Non-TOL, n=29) recipients; b) at the time of rejection from non-tolerant recipients (Non TOL REJ, n=18); In addition, liver tissue samples were also collected from the following control patient groups: a) liver transplant recipients with chronic hepatitis due to recurrent hepatitis C virus infection (HEPC, n=12); b) liver transplant recipients with typical acute cellular rejection taking place during the immediate post-transplant period (REJ, n=9); c) liver transplant recipients under maintenance immunosuppression with normal liver function and normal liver histology 1 year after transplantation (CONT-Tx, n=8); and d) non-transplanted patients undergoing surgery for colorectal liver metastases (CONT, n=10).

Experimental Variables

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Controls

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Methods

The data were normalised using quantile normalisation with Bioconductor (v2.5) Lumi package.

Additional Information

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi

Microarray
Illumina HumanHT-12 v3
110 Samples Loaded: 110
Human (Homo sapiens)
Liver Biopsy
Liver Transplant
Sample Set Spreadsheet
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Samples Preview
Sample ID !Sample_title demographic origin center liver sample group
GSM655354 Liver biopsy sample :TOL member: BX.W1.P Hospital Clinic TOL
GSM655355 Liver biopsy sample :TOL member: BX.W3.P Hospital Clinic TOL
GSM655356 Liver biopsy sample :TOL member: BX.W14.P Hospital Clinic TOL
GSM655357 Liver biopsy sample :TOL member: BX.W37.P Hospital Clinic TOL
GSM655358 Liver biopsy sample :TOL member: BX.W39.P Hospital Clinic TOL

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Links
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi
https://www.ncbi.nlm.nih.gov/pubmed/22156196

Samples Viewer / Editor

All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.

Sample ID !Sample Title Demographic origin center Liver sample group
GSM655354
Liver biopsy sample :TOL member: BX.W1.P
Hospital Clinic
TOL
GSM655355
Liver biopsy sample :TOL member: BX.W3.P
Hospital Clinic
TOL
GSM655356
Liver biopsy sample :TOL member: BX.W14.P
Hospital Clinic
TOL
GSM655357
Liver biopsy sample :TOL member: BX.W37.P
Hospital Clinic
TOL
GSM655358
Liver biopsy sample :TOL member: BX.W39.P
Hospital Clinic
TOL
GSM655359
Liver biopsy sample :TOL member: BX.W58.P
University Tor Vergata Rome
TOL
GSM655360
Liver biopsy sample :TOL member: BX.W64.P
Hospital Clinic
TOL
GSM655361
Liver biopsy sample :TOL member: BX.W9.P
Hospital Clinic
TOL
GSM655362
Liver biopsy sample :TOL member: BX.W18.P
Hospital Clinic
TOL
GSM655363
Liver biopsy sample :TOL member: BX.W63.P
Hospital Clinic
TOL
GSM655364
Liver biopsy sample :TOL member: BX.W87.P
Hospital Clinic
TOL
GSM655365
Liver biopsy sample :TOL member: BX.W129.P
Hospital Clinic
TOL
GSM655366
Liver biopsy sample :Non-TOL REJ member: BX.W2.R
Hospital Clinic
Non-TOL REJ
GSM655367
Liver biopsy sample :Non-TOL member: BX.W6.P
Hospital Clinic
Non-TOL
GSM655368
Liver biopsy sample :Non-TOL member: BX.W15.P
Hospital Clinic
Non-TOL
GSM655369
Liver biopsy sample :Non-TOL member: BX.W21.P
Hospital Clinic
Non-TOL
GSM655370
Liver biopsy sample :Non-TOL REJ member: BX.W21.R
Hospital Clinic
Non-TOL REJ
GSM655371
Liver biopsy sample :Non-TOL member: BX.W40.P
Hospital Clinic
Non-TOL
GSM655372
Liver biopsy sample :Non-TOL REJ member: BX.W66.R
Hospital Clinic
Non-TOL REJ
GSM655373
Liver biopsy sample :Non-TOL member: BX.W81.P
Hospital Clinic
Non-TOL
GSM655374
Liver biopsy sample :Non-TOL REJ member: BX.W19.R
Hospital Clinic
Non-TOL REJ
GSM655375
Liver biopsy sample :Non-TOL member: BX.W22.P
Hospital Clinic
Non-TOL
GSM655376
Liver biopsy sample :Non-TOL member: BX.W70.P
University Hospitals Leuven
Non-TOL
GSM655377
Liver biopsy sample :Non-TOL member: BX.W71.P
University Hospitals Leuven
Non-TOL
GSM655378
Liver biopsy sample :Non-TOL member: BX.W75.P
Hospital Clinic
Non-TOL
GSM655379
Liver biopsy sample :Non-TOL member: BX.W85.P
Hospital Clinic
Non-TOL
GSM655380
Liver biopsy sample :Non-TOL member: BX.W104.P
University Tor Vergata Rome
Non-TOL
GSM655381
Liver biopsy sample :Non-TOL member: BX.W106.P
University Tor Vergata Rome
Non-TOL
GSM655382
Liver biopsy sample :HEPC member: BX.P1.DEL
Hospital Clinic
HEPC
GSM655383
Liver biopsy sample :REJ member: BX.P2.RAM
Hospital Clinic
REJ
GSM655384
Liver biopsy sample :HEPC member: BX.P4.BAL
Hospital Clinic
HEPC
GSM655385
Liver biopsy sample :HEPC member: BX.P9.MON
Hospital Clinic
HEPC
GSM655386
Liver biopsy sample :REJ member: BX.P10.BUI
Hospital Clinic
REJ
GSM655387
Liver biopsy sample :REJ member: BX.P12.TAL7
Hospital Clinic
REJ
GSM655388
Liver biopsy sample :REJ member: BX.P14.RUB
Hospital Clinic
REJ
GSM655389
Liver biopsy sample :HEPC member: BX.P15.MEL
Hospital Clinic
HEPC
GSM655390
Liver biopsy sample :HEPC member: BX.P16.SAL
Hospital Clinic
HEPC
GSM655391
Liver biopsy sample :Cont-Tx member: BX.P17.MOR
Hospital Clinic
Cont-Tx
GSM655392
Liver biopsy sample :Cont-Tx member: BX.P21.ASB
Hospital Clinic
Cont-Tx
GSM655393
Liver biopsy sample :Cont-Tx member: BX.P22.AND
Hospital Clinic
Cont-Tx
GSM655394
Liver biopsy sample :Cont-Tx member: BX.P23.AVA
Hospital Clinic
Cont-Tx
GSM655395
Liver biopsy sample :TOL member: BX.W4.P
Hospital Clinic
TOL
GSM655396
Liver biopsy sample :TOL member: BX.W8.P
Hospital Clinic
TOL
GSM655397
Liver biopsy sample :TOL member: BX.W10.P
Hospital Clinic
TOL
GSM655398
Liver biopsy sample :TOL member: BX.W20.P
Hospital Clinic
TOL
GSM655399
Liver biopsy sample :TOL member: BX.W113.P
Hospital Clinic
TOL
GSM655400
Liver biopsy sample :TOL member: BX.W111.P
Hospital Clinic
TOL
GSM655401
Liver biopsy sample :Non-TOL member: BX.W12.P
Hospital Clinic
Non-TOL
GSM655402
Liver biopsy sample :Non-TOL REJ member: BX.W12.R
Hospital Clinic
Non-TOL REJ
GSM655403
Liver biopsy sample :Non-TOL REJ member: BX.W15.R
Hospital Clinic
Non-TOL REJ
GSM655404
Liver biopsy sample :Non-TOL REJ member: BX.W81.R
Hospital Clinic
Non-TOL REJ
GSM655405
Liver biopsy sample :Non-TOL member: BX.W83.P
Hospital Clinic
Non-TOL
GSM655406
Liver biopsy sample :Non-TOL REJ member: BX.W88.R
Hospital Clinic
Non-TOL REJ
GSM655407
Liver biopsy sample :Non-TOL REJ member: BX.W89.R
Hospital Clinic
Non-TOL REJ
GSM655408
Liver biopsy sample :Non-TOL REJ member: BX.W17.R
Hospital Clinic
Non-TOL REJ
GSM655409
Liver biopsy sample :Non-TOL REJ member: BX.W38.R
Hospital Clinic
Non-TOL REJ
GSM655410
Liver biopsy sample :Non-TOL member: BX.W41.P
Hospital Clinic
Non-TOL
GSM655411
Liver biopsy sample :Cont member: CT40
Hospital Clinic
Cont
GSM655412
Liver biopsy sample :TOL member: BX.W120.P
Hospital Clinic
TOL
GSM655413
Liver biopsy sample :Non-TOL member: BX.W2.P
Hospital Clinic
Non-TOL
GSM655414
Liver biopsy sample :Non-TOL REJ member: BX.W6.R
Hospital Clinic
Non-TOL REJ
GSM655415
Liver biopsy sample :Non-TOL member: BX.W11.P
Hospital Clinic
Non-TOL
GSM655416
Liver biopsy sample :Non-TOL REJ member: BX.W11.R
Hospital Clinic
Non-TOL REJ
GSM655417
Liver biopsy sample :Non-TOL REJ member: BX.W40.R
Hospital Clinic
Non-TOL REJ
GSM655418
Liver biopsy sample :Non-TOL member: BX.W65.P
Hospital Clinic
Non-TOL
GSM655419
Liver biopsy sample :Non-TOL REJ member: BX.W65.R
Hospital Clinic
Non-TOL REJ
GSM655420
Liver biopsy sample :Non-TOL member: BX.W66.P
Hospital Clinic
Non-TOL
GSM655421
Liver biopsy sample :Non-TOL REJ member: BX.W83.R
Hospital Clinic
Non-TOL REJ
GSM655422
Liver biopsy sample :Non-TOL member: BX.W88.P
Hospital Clinic
Non-TOL
GSM655423
Liver biopsy sample :Non-TOL member: BX.W89.P
Hospital Clinic
Non-TOL
GSM655424
Liver biopsy sample :Non-TOL member: BX.W109.P
Hospital Clinic
Non-TOL
GSM655425
Liver biopsy sample :Non-TOL REJ member: BX.W109.R
Hospital Clinic
Non-TOL REJ
GSM655426
Liver biopsy sample :Non-TOL member: BX.W78.P
Hospital Clinic
Non-TOL
GSM655427
Liver biopsy sample :Non-TOL member: BX.W82.P
Hospital Clinic
Non-TOL
GSM655428
Liver biopsy sample :Non-TOL member: BX.W115.P
Hospital Clinic
Non-TOL
GSM655429
Liver biopsy sample :Non-TOL member: BX.W116.P
Hospital Clinic
Non-TOL
GSM655430
Liver biopsy sample :Non-TOL member: BX.W123.P
Hospital Clinic
Non-TOL
GSM655431
Liver biopsy sample :Non-TOL member: BX.W131.P
Hospital Clinic
Non-TOL
GSM655432
Liver biopsy sample :REJ member: BX.P6.CAM
Hospital Clinic
REJ
GSM655433
Liver biopsy sample :HEPC member: BX.P7.POR
Hospital Clinic
HEPC
GSM655434
Liver biopsy sample :HEPC member: BX.P8.MOT
Hospital Clinic
HEPC
GSM655435
Liver biopsy sample :HEPC member: BX.P11.RUB
Hospital Clinic
HEPC
GSM655436
Liver biopsy sample :HEPC member: BX.P13.DEL
Hospital Clinic
HEPC
GSM655437
Liver biopsy sample :HEPC member: BX.P18.VIL
Hospital Clinic
HEPC
GSM655438
Liver biopsy sample :REJ member: BX.P19.GIM
Hospital Clinic
REJ
GSM655439
Liver biopsy sample :Cont-Tx member: BX.P20.FER
Hospital Clinic
Cont-Tx
GSM655440
Liver biopsy sample :Cont-Tx member: BX.P24.MOR
Hospital Clinic
Cont-Tx
GSM655441
Liver biopsy sample :Cont member: CT17
Hospital Clinic
Cont
GSM655442
Liver biopsy sample :Cont member: CT19
Hospital Clinic
Cont
GSM655443
Liver biopsy sample :Cont member: CT52
Hospital Clinic
Cont
GSM655444
Liver biopsy sample :Cont member: CT53
Hospital Clinic
Cont
GSM655445
Liver biopsy sample :Cont member: CT54
Hospital Clinic
Cont
GSM655446
Liver biopsy sample :TOL member: BX.W44.P
University Tor Vergata Rome
TOL
GSM655447
Liver biopsy sample :TOL member: BX.W61.P
University Tor Vergata Rome
TOL
GSM655448
Liver biopsy sample :TOL member: BX.W94.P
University Tor Vergata Rome
TOL
GSM655449
Liver biopsy sample :TOL member: BX.W130.P
Hospital Clinic
TOL
GSM655450
Liver biopsy sample :Non-TOL member: BX.W134.P
Hospital Clinic
Non-TOL
GSM655451
Liver biopsy sample :TOL member: BX.W135.P
Hospital Clinic
TOL
GSM655452
Liver biopsy sample :Cont-Tx member: BX.P29
Hospital Clinic
Cont-Tx
GSM655453
Liver biopsy sample :Cont-Tx member: BX.P30
Hospital Clinic
Cont-Tx
GSM655454
Liver biopsy sample :REJ member: BX.P25
Hospital Clinic
REJ
GSM655455
Liver biopsy sample :REJ member: BX.P26
Hospital Clinic
REJ
GSM655456
Liver biopsy sample :REJ member: BX.P27
Hospital Clinic
REJ
GSM655457
Liver biopsy sample :HEPC member: BX.P28
Hospital Clinic
HEPC
GSM655458
Liver biopsy sample :Cont member: BX.CONT.42
Hospital Clinic
Cont
GSM655459
Liver biopsy sample :Cont member: BX.CONT.48
Hospital Clinic
Cont
GSM655460
Liver biopsy sample :Cont member: BX.CONT.57
Hospital Clinic
Cont
GSM655461
Liver biopsy sample :Cont member: BX.CONT.58
Hospital Clinic
Cont
GSM655462
Liver biopsy sample :Non-TOL REJ member: BX.W108.R
Hospital Clinic
Non-TOL REJ
GSM655463
Liver biopsy sample :HEPC member: BX.P5.MAS
Hospital Clinic
HEPC

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