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Clinical

CHANGES IN THE HUMAN TRANSCRIPTOME UPON VITAMIN D SUPPLEMENTATION-GSE94138

Purpose
Subjects of a randomized controlled trial (RCT) received either vitamin D3 (n = 47) in a weekly dose of 20,000 IU or placebo (n = 47) for a period of three to five years
Hypothesis

--

Experimental Design

Blood samples for preparation of RNA were drawn from the subjects and mRNA gene expression in blood was determined using microarray analyses.

Experimental Variables

--

Controls

--

Methods
The data was preprocessed by Bioconductor lumi package (version 2.26.4). It was log2 transformed and quantile normalized.
Additional Information

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE94138

Microarray
Illumina HumanHT-12 v4
94 Samples Loaded: 94
Human (Homo sapiens)
Whole Blood
Vitamin D
standard as recommended by Illumina
Sample Set Spreadsheet
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Samples Preview
Sample ID Albumin Weight !Sample_title tissue Sex
GSM2470868 45 81.2 vitD:20215010 blood female
GSM2470869 45.3 73.6 vitD:20215018 blood male
GSM2470870 44.4 74.6 vitD:20215019 blood male
GSM2470871 42.1 51.6 vitD:20215022 blood female
GSM2470872 41.5 66.5 vitD:20215026 blood female
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File
Log2 Transformed
Raw Signal
  •   |  View in GXB »
Clinical Datasource
Links

Samples Viewer / Editor

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Sample ID Albumin Weight !Sample Title Tissue Sex Treatment Bmi Calcium Dnaassay Phosphate Sample Month Date SampleID Smoke Height Pth Dbp
GSM2470868
45
81.2
vitD:20215010
blood
female
vitamin D
31.33
2.28
10
1.27
4
20215010
0
161
6.3
3.084
GSM2470869
45.3
73.6
vitD:20215018
blood
male
vitamin D
21.98
2.27
17
1.32
5
20215018
1
183
8.8
2.849
GSM2470870
44.4
74.6
vitD:20215019
blood
male
vitamin D
26.43
2.28
18
0.71
4
20215019
0
168
15.2
3.66
GSM2470871
42.1
51.6
vitD:20215022
blood
female
Placebo
21.2
2.21
21
1.07
4
20215022
0
156
6.1
3.068
GSM2470872
41.5
66.5
vitD:20215026
blood
female
vitamin D
31.2
2.25
27
1.15
4
20215026
1
146
5.5
3.12
GSM2470873
45.6
86.4
vitD:20215027
blood
male
vitamin D
27.58
2.39
24
1.04
4
20215027
1
177
2.9
3.315
GSM2470874
45
75.8
vitD:20215035
blood
male
vitamin D
22.15
2.36
40
1.3
5
20215035
0
185
7.9
3.606
GSM2470875
44.1
93.5
vitD:20215036
blood
male
Placebo
29.18
2.36
33
1.1
5
20215036
0
179
6.6
2.742
GSM2470876
48
102
vitD:20215037
blood
male
vitamin D
29.8
2.3
32
1.03
5
20215037
0
185
4.8
4.677
GSM2470877
43.9
88
vitD:20215038
blood
male
Placebo
28.09
2.34
35
0.84
5
20215038
0
177
4.4
3.468
GSM2470878
40.5
101.3
vitD:20215040
blood
female
Placebo
32.7
2.3
41
0.93
5
20215040
NA
176
7.8
3.287
GSM2470879
44.3
81.7
vitD:20215044
blood
female
Placebo
27.94
2.22
37
1.05
5
20215044
0
171
11.3
3.347
GSM2470880
45.3
87.6
vitD:20215048
blood
male
Placebo
27.65
2.4
55
1.1
5
20215048
0
178
6.1
2.747
GSM2470881
43.5
89.7
vitD:20215051
blood
male
Placebo
30.68
2.24
48
0.91
5
20215051
0
171
7
3.707
GSM2470882
46
84.2
vitD:20215055
blood
male
Placebo
30.19
2.31
58
0.76
6
20215055
0
167
6.9
3.624
GSM2470883
43
99.8
vitD:20215056
blood
female
Placebo
38.98
2.22
49
1.13
5
20215056
0
160
5.5
3.161
GSM2470884
39.6
81.8
vitD:20215059
blood
female
Placebo
31.17
2.3
65
0.99
6
20215059
0
162
6.3
3.024
GSM2470885
44.1
86.8
vitD:20215067
blood
male
Placebo
28.02
2.26
61
0.82
6
20215067
0
176
7.8
3.449
GSM2470886
NA
63.2
vitD:20215071
blood
female
vitamin D
28.09
2.36
64
1.09
6
20215071
0
150
5
3.546
GSM2470887
43
111.7
vitD:20215073
blood
male
Placebo
35.25
2.28
66
0.94
6
20215073
0
178
8.2
3.515
GSM2470888
42.8
96
vitD:20215077
blood
male
vitamin D
30.99
2.33
67
0.99
6
20215077
0
176
6.1
2.674
GSM2470889
40.1
70.1
vitD:20215078
blood
female
Placebo
25.44
2.51
69
1.08
6
20215078
1
166
2.8
2.33
GSM2470890
40.8
78
vitD:20215080
blood
male
Placebo
25.18
2.31
79
1.14
6
20215080
0
176
4.7
2.439
GSM2470891
40.9
88.9
vitD:20215081
blood
female
vitamin D
36.53
2.41
68
1.01
6
20215081
0
156
6.3
2.841
GSM2470892
44
76.4
vitD:20215082
blood
female
vitamin D
28.06
2.31
78
1.05
6
20215082
0
165
4.6
3.162
GSM2470893
44.3
61.3
vitD:20215083
blood
female
Placebo
23.36
2.35
70
1.24
6
20215083
1
162
5.9
3.875
GSM2470894
45.1
62.8
vitD:20215085
blood
male
Placebo
24.23
2.27
71
0.83
6
20215085
0
161
7
2.943
GSM2470895
44.3
50.4
vitD:20215088
blood
female
vitamin D
22.1
2.38
74
0.84
6
20215088
0
151
4.8
3.293
GSM2470896
45.5
104.5
vitD:20215099
blood
male
vitamin D
34.92
2.27
90
0.89
6
20215099
0
173
5.9
2.678
GSM2470897
41.9
90.3
vitD:20215102
blood
male
Placebo
28.18
2.24
86
0.96
6
20215102
0
179
6.4
2.795
GSM2470898
43.4
84.6
vitD:20215104
blood
male
vitamin D
26.4
2.31
89
0.73
6
20215104
0
179
6.1
2.619
GSM2470899
39.3
49.7
vitD:20215105
blood
female
Placebo
20.69
2.34
93
1.24
7
20215105
0
155
5.9
3.596
GSM2470900
43.5
91.6
vitD:20215109
blood
male
vitamin D
29.57
2.2
97
0.8
7
20215109
0
176
4.2
3.187
GSM2470901
41.6
86.1
vitD:20215113
blood
male
Placebo
27.17
2.22
106
1.05
7
20215113
0
178
2.8
3.284
GSM2470902
41.8
74.7
vitD:20215114
blood
male
vitamin D
25.25
2.21
121
1.09
8
20215114
0
172
4.4
2.592
GSM2470903
43.8
94.7
vitD:20215115
blood
male
vitamin D
32.39
2.27
100
1.11
7
20215115
0
171
6.5
3.105
GSM2470904
40.4
73.4
vitD:20215121
blood
female
Placebo
25.7
2.3
105
1
7
20215121
0
169
5.2
3.373
GSM2470905
44.2
84.6
vitD:20215128
blood
female
vitamin D
31.45
2.44
104
1.09
7
20215128
0
164
3.2
3.27
GSM2470906
42.1
67
vitD:20215223
blood
female
vitamin D
25.85
2.27
206
1.25
5
20215223
0
161
4.5
3.238
GSM2470907
45.3
84.5
vitD:20215258
blood
female
vitamin D
32.6
2.37
236
1.01
2
20215258
0
161
4.1
3.529
GSM2470908
44.8
81.3
vitD:20215269
blood
female
vitamin D
33.84
2.3
243
1.08
2
20215269
0
155
10.3
3.217
GSM2470909
39.6
66.7
vitD:20215284
blood
female
Placebo
25.42
2.31
266
1.02
2
20215284
0
162
3.3
2.866
GSM2470910
42.7
81
vitD:20215285
blood
male
vitamin D
30.12
2.45
268
1.18
2
20215285
1
164
5.7
2.865
GSM2470911
47.2
79.2
vitD:20215291
blood
male
Placebo
25.28
2.32
269
0.99
2
20215291
0
177
5.7
3.284
GSM2470912
47
89.8
vitD:20215292
blood
male
vitamin D
28.66
2.32
271
0.84
3
20215292
0
177
4.1
3.206
GSM2470913
41.8
109
vitD:20215295
blood
male
vitamin D
30.84
2.25
273
0.9
2
20215295
0
188
4.4
2.879
GSM2470914
45.5
73.1
vitD:20215297
blood
male
Placebo
23.07
2.3
278
0.95
3
20215297
1
178
7.2
2.531
GSM2470915
44.7
96.1
vitD:20215299
blood
male
vitamin D
31.74
2.23
274
0.98
3
20215299
0
174
3.8
3.176
GSM2470916
45.1
90.3
vitD:20215300
blood
male
Placebo
27.26
2.37
277
0.99
2
20215300
0
182
3.3
3.496
GSM2470917
45.2
95.3
vitD:20215305
blood
male
Placebo
30.08
2.25
280
0.81
3
20215305
0
178
6.9
2.869
GSM2470918
44.9
97.5
vitD:20215306
blood
male
Placebo
28.8
2.32
282
0.97
3
20215306
0
184
5.2
2.692
GSM2470919
45.1
72.8
vitD:20215307
blood
female
vitamin D
27.4
2.38
284
1.14
3
20215307
0
163
6.2
3.116
GSM2470920
41.6
90.6
vitD:20215322
blood
male
Placebo
29.58
2.29
294
1.1
4
20215322
0
175
4.8
3.155
GSM2470921
38.8
72.4
vitD:20215323
blood
male
vitamin D
23.11
2.35
295
0.96
4
20215323
0
177
7.1
4.228
GSM2470922
46.7
105.8
vitD:20215324
blood
male
Placebo
33.77
2.28
300
1.18
4
20215324
0
177
5.2
2.815
GSM2470923
38.1
57.3
vitD:20215335
blood
female
Placebo
22.11
2.36
310
1
4
20215335
0
161
4.5
3.407
GSM2470924
42.6
82.5
vitD:20215336
blood
male
vitamin D
28.55
2.27
308
1.14
4
20215336
0
170
7.2
2.772
GSM2470925
44.1
93.5
vitD:20215338
blood
female
vitamin D
35.19
2.3
332
0.84
6
20215338
1
163
4.8
3.021
GSM2470926
44.3
80.5
vitD:20215339
blood
male
Placebo
27.85
2.32
309
0.89
4
20215339
0
170
4.5
3.276
GSM2470927
43.1
79.2
vitD:20215341
blood
female
vitamin D
30.94
2.37
312
1.15
6
20215341
0
160
5
3.278
GSM2470928
46.4
90.7
vitD:20215345
blood
male
vitamin D
27.69
2.3
314
0.84
4
20215345
1
181
6.3
3.679
GSM2470929
41.6
76
vitD:20215349
blood
male
vitamin D
22.45
2.22
320
0.9
5
20215349
0
184
4.4
2.999
GSM2470930
41.7
79.2
vitD:20215353
blood
male
vitamin D
26.16
2.26
324
0.95
5
20215353
1
174
5.9
3.059
GSM2470931
42.5
71.1
vitD:20215354
blood
female
vitamin D
26.12
2.29
326
1.23
5
20215354
1
165
6.3
3.369
GSM2470932
45.9
105.7
vitD:20215357
blood
male
Placebo
33.74
2.23
347
1.12
7
20215357
0
177
7.6
3.301
GSM2470933
40.8
61.7
vitD:20215360
blood
female
vitamin D
23.8
2.28
328
1.24
7
20215360
0
161
4.5
3.111
GSM2470934
45.4
73
vitD:20215362
blood
female
Placebo
30.78
2.36
342
1.21
7
20215362
0
154
6.3
2.998
GSM2470935
43.6
88
vitD:20215366
blood
male
Placebo
30.45
2.16
343
0.68
7
20215366
0
170
6.5
3.796
GSM2470936
NA
88.1
vitD:20215368
blood
male
Placebo
31.97
2.21
348
0.81
7
20215368
0
166
10.2
2.66
GSM2470937
41.4
106.6
vitD:20215369
blood
male
vitamin D
36.03
2.35
337
0.96
6
20215369
0
172
14.5
3.176
GSM2470938
41.7
85.6
vitD:20215370
blood
male
Placebo
27.02
2.41
329
1.49
6
20215370
0
178
2.5
3.261
GSM2470939
47.4
72.9
vitD:20215372
blood
female
vitamin D
26.14
2.37
354
0.86
8
20215372
0
167
6.3
3.141
GSM2470940
NA
73.1
vitD:20215383
blood
female
vitamin D
29.66
2.39
349
1.03
7
20215383
0
157
3.1
3.283
GSM2470941
42.5
77.4
vitD:20215389
blood
male
vitamin D
29.49
2.28
333
1.12
6
20215389
0
162
5.2
3.424
GSM2470942
38.8
78.5
vitD:20215391
blood
female
vitamin D
26.85
2.21
334
1.21
6
20215391
1
171
4.5
3.202
GSM2470943
47
104.2
vitD:20215482
blood
male
Placebo
28.86
2.39
450
0.84
5
20215482
0
190
3.4
2.91
GSM2470944
48.8
87.1
vitD:20215524
blood
male
Placebo
29.1
2.42
487
1.03
2
20215524
0
173
4.4
3.38
GSM2470945
47.1
102.5
vitD:20215526
blood
male
vitamin D
28.69
2.42
489
1.13
2
20215526
0
189
4.5
3.2
GSM2470946
43.8
100.5
vitD:20215528
blood
male
Placebo
31.37
2.32
493
1.17
2
20215528
1
179
2.6
2.712
GSM2470947
45.3
94.8
vitD:20215529
blood
male
Placebo
30.26
2.39
491
1.02
2
20215529
0
177
4.8
2.7
GSM2470948
44.4
100
vitD:20215531
blood
male
Placebo
32.28
2.3
494
1.16
2
20215531
0
176
4.5
3.263
GSM2470949
47.1
121.6
vitD:20215539
blood
male
Placebo
37.12
2.39
499
1.01
2
20215539
0
181
2.8
3.373
GSM2470950
44.3
100.5
vitD:20215541
blood
male
Placebo
29.36
2.29
497
0.88
2
20215541
0
185
6.5
2.588
GSM2470951
44
102.5
vitD:20215543
blood
male
Placebo
34.25
2.21
506
0.95
2
20215543
0
173
6.9
2.506
GSM2470952
45.3
102.4
vitD:20215544
blood
male
vitamin D
33.82
2.49
517
0.91
3
20215544
0
174
3.7
3.038
GSM2470953
44.9
85.6
vitD:20215545
blood
male
Placebo
28.6
2.15
509
0.7
2
20215545
0
173
5.9
3.621
GSM2470954
43.2
103.3
vitD:20215546
blood
male
vitamin D
35.33
2.23
510
0.98
3
20215546
0
171
6.2
2.979
GSM2470955
42.9
89.5
vitD:20215548
blood
male
Placebo
29.22
2.26
507
1.05
3
20215548
0
175
4.6
3.337
GSM2470956
43.5
90.3
vitD:20215549
blood
male
vitamin D
27.56
2.27
508
1.26
3
20215549
0
181
5.6
2.762
GSM2470957
48.2
92.7
vitD:20215551
blood
male
vitamin D
28.61
2.48
513
0.84
3
20215551
0
180
6.9
2.487
GSM2470958
45.8
76.1
vitD:20215552
blood
male
Placebo
28.64
2.34
515
1.21
3
20215552
0
163
2.7
2.807
GSM2470959
46.4
77.6
vitD:20215553
blood
male
vitamin D
27.82
2.41
512
1.01
3
20215553
0
167
5.9
2.199
GSM2470960
44.8
93.5
vitD:20215555
blood
male
Placebo
30.88
2.25
516
1.26
3
20215555
0
174
6.3
3.036
GSM2470961
40.3
95.7
vitD:20215557
blood
male
vitamin D
31.25
2.16
520
0.95
3
20215557
1
175
4.4
2.886

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