CHANGES IN THE HUMAN TRANSCRIPTOME UPON VITAMIN D SUPPLEMENTATION-GSE94138
Subjects of a randomized controlled trial (RCT) received either vitamin D3 (n = 47) in a weekly dose of 20,000 IU or placebo (n = 47) for a period of three to five years |
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Blood samples for preparation of RNA were drawn from the subjects and mRNA gene expression in blood was determined using microarray analyses.
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The data was preprocessed by Bioconductor lumi package (version 2.26.4). It was log2 transformed and quantile normalized. |
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE94138
Sample ID | Albumin | Weight | !Sample_title | tissue | Sex |
---|---|---|---|---|---|
GSM2470868 | 45 | 81.2 | vitD:20215010 | blood | female |
GSM2470869 | 45.3 | 73.6 | vitD:20215018 | blood | male |
GSM2470870 | 44.4 | 74.6 | vitD:20215019 | blood | male |
GSM2470871 | 42.1 | 51.6 | vitD:20215022 | blood | female |
GSM2470872 | 41.5 | 66.5 | vitD:20215026 | blood | female |
File |
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Sample ID | Albumin | Weight | !Sample Title | Tissue | Sex | Treatment | Bmi | Calcium | Dnaassay | Phosphate | Sample Month Date | SampleID | Smoke | Height | Pth | Dbp |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GSM2470868 | 45 |
81.2 |
vitD:20215010 |
blood |
female |
vitamin D |
31.33 |
2.28 |
10 |
1.27 |
4 |
20215010 |
0 |
161 |
6.3 |
3.084 |
GSM2470869 | 45.3 |
73.6 |
vitD:20215018 |
blood |
male |
vitamin D |
21.98 |
2.27 |
17 |
1.32 |
5 |
20215018 |
1 |
183 |
8.8 |
2.849 |
GSM2470870 | 44.4 |
74.6 |
vitD:20215019 |
blood |
male |
vitamin D |
26.43 |
2.28 |
18 |
0.71 |
4 |
20215019 |
0 |
168 |
15.2 |
3.66 |
GSM2470871 | 42.1 |
51.6 |
vitD:20215022 |
blood |
female |
Placebo |
21.2 |
2.21 |
21 |
1.07 |
4 |
20215022 |
0 |
156 |
6.1 |
3.068 |
GSM2470872 | 41.5 |
66.5 |
vitD:20215026 |
blood |
female |
vitamin D |
31.2 |
2.25 |
27 |
1.15 |
4 |
20215026 |
1 |
146 |
5.5 |
3.12 |
GSM2470873 | 45.6 |
86.4 |
vitD:20215027 |
blood |
male |
vitamin D |
27.58 |
2.39 |
24 |
1.04 |
4 |
20215027 |
1 |
177 |
2.9 |
3.315 |
GSM2470874 | 45 |
75.8 |
vitD:20215035 |
blood |
male |
vitamin D |
22.15 |
2.36 |
40 |
1.3 |
5 |
20215035 |
0 |
185 |
7.9 |
3.606 |
GSM2470875 | 44.1 |
93.5 |
vitD:20215036 |
blood |
male |
Placebo |
29.18 |
2.36 |
33 |
1.1 |
5 |
20215036 |
0 |
179 |
6.6 |
2.742 |
GSM2470876 | 48 |
102 |
vitD:20215037 |
blood |
male |
vitamin D |
29.8 |
2.3 |
32 |
1.03 |
5 |
20215037 |
0 |
185 |
4.8 |
4.677 |
GSM2470877 | 43.9 |
88 |
vitD:20215038 |
blood |
male |
Placebo |
28.09 |
2.34 |
35 |
0.84 |
5 |
20215038 |
0 |
177 |
4.4 |
3.468 |
GSM2470878 | 40.5 |
101.3 |
vitD:20215040 |
blood |
female |
Placebo |
32.7 |
2.3 |
41 |
0.93 |
5 |
20215040 |
NA |
176 |
7.8 |
3.287 |
GSM2470879 | 44.3 |
81.7 |
vitD:20215044 |
blood |
female |
Placebo |
27.94 |
2.22 |
37 |
1.05 |
5 |
20215044 |
0 |
171 |
11.3 |
3.347 |
GSM2470880 | 45.3 |
87.6 |
vitD:20215048 |
blood |
male |
Placebo |
27.65 |
2.4 |
55 |
1.1 |
5 |
20215048 |
0 |
178 |
6.1 |
2.747 |
GSM2470881 | 43.5 |
89.7 |
vitD:20215051 |
blood |
male |
Placebo |
30.68 |
2.24 |
48 |
0.91 |
5 |
20215051 |
0 |
171 |
7 |
3.707 |
GSM2470882 | 46 |
84.2 |
vitD:20215055 |
blood |
male |
Placebo |
30.19 |
2.31 |
58 |
0.76 |
6 |
20215055 |
0 |
167 |
6.9 |
3.624 |
GSM2470883 | 43 |
99.8 |
vitD:20215056 |
blood |
female |
Placebo |
38.98 |
2.22 |
49 |
1.13 |
5 |
20215056 |
0 |
160 |
5.5 |
3.161 |
GSM2470884 | 39.6 |
81.8 |
vitD:20215059 |
blood |
female |
Placebo |
31.17 |
2.3 |
65 |
0.99 |
6 |
20215059 |
0 |
162 |
6.3 |
3.024 |
GSM2470885 | 44.1 |
86.8 |
vitD:20215067 |
blood |
male |
Placebo |
28.02 |
2.26 |
61 |
0.82 |
6 |
20215067 |
0 |
176 |
7.8 |
3.449 |
GSM2470886 | NA |
63.2 |
vitD:20215071 |
blood |
female |
vitamin D |
28.09 |
2.36 |
64 |
1.09 |
6 |
20215071 |
0 |
150 |
5 |
3.546 |
GSM2470887 | 43 |
111.7 |
vitD:20215073 |
blood |
male |
Placebo |
35.25 |
2.28 |
66 |
0.94 |
6 |
20215073 |
0 |
178 |
8.2 |
3.515 |
GSM2470888 | 42.8 |
96 |
vitD:20215077 |
blood |
male |
vitamin D |
30.99 |
2.33 |
67 |
0.99 |
6 |
20215077 |
0 |
176 |
6.1 |
2.674 |
GSM2470889 | 40.1 |
70.1 |
vitD:20215078 |
blood |
female |
Placebo |
25.44 |
2.51 |
69 |
1.08 |
6 |
20215078 |
1 |
166 |
2.8 |
2.33 |
GSM2470890 | 40.8 |
78 |
vitD:20215080 |
blood |
male |
Placebo |
25.18 |
2.31 |
79 |
1.14 |
6 |
20215080 |
0 |
176 |
4.7 |
2.439 |
GSM2470891 | 40.9 |
88.9 |
vitD:20215081 |
blood |
female |
vitamin D |
36.53 |
2.41 |
68 |
1.01 |
6 |
20215081 |
0 |
156 |
6.3 |
2.841 |
GSM2470892 | 44 |
76.4 |
vitD:20215082 |
blood |
female |
vitamin D |
28.06 |
2.31 |
78 |
1.05 |
6 |
20215082 |
0 |
165 |
4.6 |
3.162 |
GSM2470893 | 44.3 |
61.3 |
vitD:20215083 |
blood |
female |
Placebo |
23.36 |
2.35 |
70 |
1.24 |
6 |
20215083 |
1 |
162 |
5.9 |
3.875 |
GSM2470894 | 45.1 |
62.8 |
vitD:20215085 |
blood |
male |
Placebo |
24.23 |
2.27 |
71 |
0.83 |
6 |
20215085 |
0 |
161 |
7 |
2.943 |
GSM2470895 | 44.3 |
50.4 |
vitD:20215088 |
blood |
female |
vitamin D |
22.1 |
2.38 |
74 |
0.84 |
6 |
20215088 |
0 |
151 |
4.8 |
3.293 |
GSM2470896 | 45.5 |
104.5 |
vitD:20215099 |
blood |
male |
vitamin D |
34.92 |
2.27 |
90 |
0.89 |
6 |
20215099 |
0 |
173 |
5.9 |
2.678 |
GSM2470897 | 41.9 |
90.3 |
vitD:20215102 |
blood |
male |
Placebo |
28.18 |
2.24 |
86 |
0.96 |
6 |
20215102 |
0 |
179 |
6.4 |
2.795 |
GSM2470898 | 43.4 |
84.6 |
vitD:20215104 |
blood |
male |
vitamin D |
26.4 |
2.31 |
89 |
0.73 |
6 |
20215104 |
0 |
179 |
6.1 |
2.619 |
GSM2470899 | 39.3 |
49.7 |
vitD:20215105 |
blood |
female |
Placebo |
20.69 |
2.34 |
93 |
1.24 |
7 |
20215105 |
0 |
155 |
5.9 |
3.596 |
GSM2470900 | 43.5 |
91.6 |
vitD:20215109 |
blood |
male |
vitamin D |
29.57 |
2.2 |
97 |
0.8 |
7 |
20215109 |
0 |
176 |
4.2 |
3.187 |
GSM2470901 | 41.6 |
86.1 |
vitD:20215113 |
blood |
male |
Placebo |
27.17 |
2.22 |
106 |
1.05 |
7 |
20215113 |
0 |
178 |
2.8 |
3.284 |
GSM2470902 | 41.8 |
74.7 |
vitD:20215114 |
blood |
male |
vitamin D |
25.25 |
2.21 |
121 |
1.09 |
8 |
20215114 |
0 |
172 |
4.4 |
2.592 |
GSM2470903 | 43.8 |
94.7 |
vitD:20215115 |
blood |
male |
vitamin D |
32.39 |
2.27 |
100 |
1.11 |
7 |
20215115 |
0 |
171 |
6.5 |
3.105 |
GSM2470904 | 40.4 |
73.4 |
vitD:20215121 |
blood |
female |
Placebo |
25.7 |
2.3 |
105 |
1 |
7 |
20215121 |
0 |
169 |
5.2 |
3.373 |
GSM2470905 | 44.2 |
84.6 |
vitD:20215128 |
blood |
female |
vitamin D |
31.45 |
2.44 |
104 |
1.09 |
7 |
20215128 |
0 |
164 |
3.2 |
3.27 |
GSM2470906 | 42.1 |
67 |
vitD:20215223 |
blood |
female |
vitamin D |
25.85 |
2.27 |
206 |
1.25 |
5 |
20215223 |
0 |
161 |
4.5 |
3.238 |
GSM2470907 | 45.3 |
84.5 |
vitD:20215258 |
blood |
female |
vitamin D |
32.6 |
2.37 |
236 |
1.01 |
2 |
20215258 |
0 |
161 |
4.1 |
3.529 |
GSM2470908 | 44.8 |
81.3 |
vitD:20215269 |
blood |
female |
vitamin D |
33.84 |
2.3 |
243 |
1.08 |
2 |
20215269 |
0 |
155 |
10.3 |
3.217 |
GSM2470909 | 39.6 |
66.7 |
vitD:20215284 |
blood |
female |
Placebo |
25.42 |
2.31 |
266 |
1.02 |
2 |
20215284 |
0 |
162 |
3.3 |
2.866 |
GSM2470910 | 42.7 |
81 |
vitD:20215285 |
blood |
male |
vitamin D |
30.12 |
2.45 |
268 |
1.18 |
2 |
20215285 |
1 |
164 |
5.7 |
2.865 |
GSM2470911 | 47.2 |
79.2 |
vitD:20215291 |
blood |
male |
Placebo |
25.28 |
2.32 |
269 |
0.99 |
2 |
20215291 |
0 |
177 |
5.7 |
3.284 |
GSM2470912 | 47 |
89.8 |
vitD:20215292 |
blood |
male |
vitamin D |
28.66 |
2.32 |
271 |
0.84 |
3 |
20215292 |
0 |
177 |
4.1 |
3.206 |
GSM2470913 | 41.8 |
109 |
vitD:20215295 |
blood |
male |
vitamin D |
30.84 |
2.25 |
273 |
0.9 |
2 |
20215295 |
0 |
188 |
4.4 |
2.879 |
GSM2470914 | 45.5 |
73.1 |
vitD:20215297 |
blood |
male |
Placebo |
23.07 |
2.3 |
278 |
0.95 |
3 |
20215297 |
1 |
178 |
7.2 |
2.531 |
GSM2470915 | 44.7 |
96.1 |
vitD:20215299 |
blood |
male |
vitamin D |
31.74 |
2.23 |
274 |
0.98 |
3 |
20215299 |
0 |
174 |
3.8 |
3.176 |
GSM2470916 | 45.1 |
90.3 |
vitD:20215300 |
blood |
male |
Placebo |
27.26 |
2.37 |
277 |
0.99 |
2 |
20215300 |
0 |
182 |
3.3 |
3.496 |
GSM2470917 | 45.2 |
95.3 |
vitD:20215305 |
blood |
male |
Placebo |
30.08 |
2.25 |
280 |
0.81 |
3 |
20215305 |
0 |
178 |
6.9 |
2.869 |
GSM2470918 | 44.9 |
97.5 |
vitD:20215306 |
blood |
male |
Placebo |
28.8 |
2.32 |
282 |
0.97 |
3 |
20215306 |
0 |
184 |
5.2 |
2.692 |
GSM2470919 | 45.1 |
72.8 |
vitD:20215307 |
blood |
female |
vitamin D |
27.4 |
2.38 |
284 |
1.14 |
3 |
20215307 |
0 |
163 |
6.2 |
3.116 |
GSM2470920 | 41.6 |
90.6 |
vitD:20215322 |
blood |
male |
Placebo |
29.58 |
2.29 |
294 |
1.1 |
4 |
20215322 |
0 |
175 |
4.8 |
3.155 |
GSM2470921 | 38.8 |
72.4 |
vitD:20215323 |
blood |
male |
vitamin D |
23.11 |
2.35 |
295 |
0.96 |
4 |
20215323 |
0 |
177 |
7.1 |
4.228 |
GSM2470922 | 46.7 |
105.8 |
vitD:20215324 |
blood |
male |
Placebo |
33.77 |
2.28 |
300 |
1.18 |
4 |
20215324 |
0 |
177 |
5.2 |
2.815 |
GSM2470923 | 38.1 |
57.3 |
vitD:20215335 |
blood |
female |
Placebo |
22.11 |
2.36 |
310 |
1 |
4 |
20215335 |
0 |
161 |
4.5 |
3.407 |
GSM2470924 | 42.6 |
82.5 |
vitD:20215336 |
blood |
male |
vitamin D |
28.55 |
2.27 |
308 |
1.14 |
4 |
20215336 |
0 |
170 |
7.2 |
2.772 |
GSM2470925 | 44.1 |
93.5 |
vitD:20215338 |
blood |
female |
vitamin D |
35.19 |
2.3 |
332 |
0.84 |
6 |
20215338 |
1 |
163 |
4.8 |
3.021 |
GSM2470926 | 44.3 |
80.5 |
vitD:20215339 |
blood |
male |
Placebo |
27.85 |
2.32 |
309 |
0.89 |
4 |
20215339 |
0 |
170 |
4.5 |
3.276 |
GSM2470927 | 43.1 |
79.2 |
vitD:20215341 |
blood |
female |
vitamin D |
30.94 |
2.37 |
312 |
1.15 |
6 |
20215341 |
0 |
160 |
5 |
3.278 |
GSM2470928 | 46.4 |
90.7 |
vitD:20215345 |
blood |
male |
vitamin D |
27.69 |
2.3 |
314 |
0.84 |
4 |
20215345 |
1 |
181 |
6.3 |
3.679 |
GSM2470929 | 41.6 |
76 |
vitD:20215349 |
blood |
male |
vitamin D |
22.45 |
2.22 |
320 |
0.9 |
5 |
20215349 |
0 |
184 |
4.4 |
2.999 |
GSM2470930 | 41.7 |
79.2 |
vitD:20215353 |
blood |
male |
vitamin D |
26.16 |
2.26 |
324 |
0.95 |
5 |
20215353 |
1 |
174 |
5.9 |
3.059 |
GSM2470931 | 42.5 |
71.1 |
vitD:20215354 |
blood |
female |
vitamin D |
26.12 |
2.29 |
326 |
1.23 |
5 |
20215354 |
1 |
165 |
6.3 |
3.369 |
GSM2470932 | 45.9 |
105.7 |
vitD:20215357 |
blood |
male |
Placebo |
33.74 |
2.23 |
347 |
1.12 |
7 |
20215357 |
0 |
177 |
7.6 |
3.301 |
GSM2470933 | 40.8 |
61.7 |
vitD:20215360 |
blood |
female |
vitamin D |
23.8 |
2.28 |
328 |
1.24 |
7 |
20215360 |
0 |
161 |
4.5 |
3.111 |
GSM2470934 | 45.4 |
73 |
vitD:20215362 |
blood |
female |
Placebo |
30.78 |
2.36 |
342 |
1.21 |
7 |
20215362 |
0 |
154 |
6.3 |
2.998 |
GSM2470935 | 43.6 |
88 |
vitD:20215366 |
blood |
male |
Placebo |
30.45 |
2.16 |
343 |
0.68 |
7 |
20215366 |
0 |
170 |
6.5 |
3.796 |
GSM2470936 | NA |
88.1 |
vitD:20215368 |
blood |
male |
Placebo |
31.97 |
2.21 |
348 |
0.81 |
7 |
20215368 |
0 |
166 |
10.2 |
2.66 |
GSM2470937 | 41.4 |
106.6 |
vitD:20215369 |
blood |
male |
vitamin D |
36.03 |
2.35 |
337 |
0.96 |
6 |
20215369 |
0 |
172 |
14.5 |
3.176 |
GSM2470938 | 41.7 |
85.6 |
vitD:20215370 |
blood |
male |
Placebo |
27.02 |
2.41 |
329 |
1.49 |
6 |
20215370 |
0 |
178 |
2.5 |
3.261 |
GSM2470939 | 47.4 |
72.9 |
vitD:20215372 |
blood |
female |
vitamin D |
26.14 |
2.37 |
354 |
0.86 |
8 |
20215372 |
0 |
167 |
6.3 |
3.141 |
GSM2470940 | NA |
73.1 |
vitD:20215383 |
blood |
female |
vitamin D |
29.66 |
2.39 |
349 |
1.03 |
7 |
20215383 |
0 |
157 |
3.1 |
3.283 |
GSM2470941 | 42.5 |
77.4 |
vitD:20215389 |
blood |
male |
vitamin D |
29.49 |
2.28 |
333 |
1.12 |
6 |
20215389 |
0 |
162 |
5.2 |
3.424 |
GSM2470942 | 38.8 |
78.5 |
vitD:20215391 |
blood |
female |
vitamin D |
26.85 |
2.21 |
334 |
1.21 |
6 |
20215391 |
1 |
171 |
4.5 |
3.202 |
GSM2470943 | 47 |
104.2 |
vitD:20215482 |
blood |
male |
Placebo |
28.86 |
2.39 |
450 |
0.84 |
5 |
20215482 |
0 |
190 |
3.4 |
2.91 |
GSM2470944 | 48.8 |
87.1 |
vitD:20215524 |
blood |
male |
Placebo |
29.1 |
2.42 |
487 |
1.03 |
2 |
20215524 |
0 |
173 |
4.4 |
3.38 |
GSM2470945 | 47.1 |
102.5 |
vitD:20215526 |
blood |
male |
vitamin D |
28.69 |
2.42 |
489 |
1.13 |
2 |
20215526 |
0 |
189 |
4.5 |
3.2 |
GSM2470946 | 43.8 |
100.5 |
vitD:20215528 |
blood |
male |
Placebo |
31.37 |
2.32 |
493 |
1.17 |
2 |
20215528 |
1 |
179 |
2.6 |
2.712 |
GSM2470947 | 45.3 |
94.8 |
vitD:20215529 |
blood |
male |
Placebo |
30.26 |
2.39 |
491 |
1.02 |
2 |
20215529 |
0 |
177 |
4.8 |
2.7 |
GSM2470948 | 44.4 |
100 |
vitD:20215531 |
blood |
male |
Placebo |
32.28 |
2.3 |
494 |
1.16 |
2 |
20215531 |
0 |
176 |
4.5 |
3.263 |
GSM2470949 | 47.1 |
121.6 |
vitD:20215539 |
blood |
male |
Placebo |
37.12 |
2.39 |
499 |
1.01 |
2 |
20215539 |
0 |
181 |
2.8 |
3.373 |
GSM2470950 | 44.3 |
100.5 |
vitD:20215541 |
blood |
male |
Placebo |
29.36 |
2.29 |
497 |
0.88 |
2 |
20215541 |
0 |
185 |
6.5 |
2.588 |
GSM2470951 | 44 |
102.5 |
vitD:20215543 |
blood |
male |
Placebo |
34.25 |
2.21 |
506 |
0.95 |
2 |
20215543 |
0 |
173 |
6.9 |
2.506 |
GSM2470952 | 45.3 |
102.4 |
vitD:20215544 |
blood |
male |
vitamin D |
33.82 |
2.49 |
517 |
0.91 |
3 |
20215544 |
0 |
174 |
3.7 |
3.038 |
GSM2470953 | 44.9 |
85.6 |
vitD:20215545 |
blood |
male |
Placebo |
28.6 |
2.15 |
509 |
0.7 |
2 |
20215545 |
0 |
173 |
5.9 |
3.621 |
GSM2470954 | 43.2 |
103.3 |
vitD:20215546 |
blood |
male |
vitamin D |
35.33 |
2.23 |
510 |
0.98 |
3 |
20215546 |
0 |
171 |
6.2 |
2.979 |
GSM2470955 | 42.9 |
89.5 |
vitD:20215548 |
blood |
male |
Placebo |
29.22 |
2.26 |
507 |
1.05 |
3 |
20215548 |
0 |
175 |
4.6 |
3.337 |
GSM2470956 | 43.5 |
90.3 |
vitD:20215549 |
blood |
male |
vitamin D |
27.56 |
2.27 |
508 |
1.26 |
3 |
20215549 |
0 |
181 |
5.6 |
2.762 |
GSM2470957 | 48.2 |
92.7 |
vitD:20215551 |
blood |
male |
vitamin D |
28.61 |
2.48 |
513 |
0.84 |
3 |
20215551 |
0 |
180 |
6.9 |
2.487 |
GSM2470958 | 45.8 |
76.1 |
vitD:20215552 |
blood |
male |
Placebo |
28.64 |
2.34 |
515 |
1.21 |
3 |
20215552 |
0 |
163 |
2.7 |
2.807 |
GSM2470959 | 46.4 |
77.6 |
vitD:20215553 |
blood |
male |
vitamin D |
27.82 |
2.41 |
512 |
1.01 |
3 |
20215553 |
0 |
167 |
5.9 |
2.199 |
GSM2470960 | 44.8 |
93.5 |
vitD:20215555 |
blood |
male |
Placebo |
30.88 |
2.25 |
516 |
1.26 |
3 |
20215555 |
0 |
174 |
6.3 |
3.036 |
GSM2470961 | 40.3 |
95.7 |
vitD:20215557 |
blood |
male |
vitamin D |
31.25 |
2.16 |
520 |
0.95 |
3 |
20215557 |
1 |
175 |
4.4 |
2.886 |
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